Endocrine Abstracts

Potassium-dependent sodium/calcium exchanger (NCKX3) is expressed in the brain, smooth muscle, the uterus, and intestine. NCKX3 gene plays a role in transporting intracellular calcium and potassium ions across the cell membrane in exchange for extracellular sodium ions. This gene is also associated with calcium metabolism in bones. Tight junctions have functional barriers for material transport and osmotic balance, which are regulated by calcium metabolism. Claudin, o...

There have been raising concerns in the effects of endocrine disrupting chemicals like triclosan (TCS) on the embryo development. Triclosan (TCS) is commonly present in household and personal wash products We hypothesize that exposure to TCS during early stage of development could alter brain development affecting behavior. To test this hypothesis, primary cortical neurons were exposure to TCS with/without estrogen antiestrogen ICI 182780 from day in vitro 1 to 4. We also addr...

Perinatal action of estrogens or aromatizable steroids at the central nervous system level is responsible for brain development. 4-tert-octylphenol (OP) is knows as an endocrine disrupting chemical (EDC) that is widespread estrogenic chemical used in the costumer produces. Thus, we hypothesis that through early contact with the central nervous system, OP could alter the processes affecting behavior. In this study, primary cortical neurons were exposure to OP (10–6</...